1 Cruezeiro ND(1944)P#132.
10 Mil Reis E17A(1925) P#39d.
I'm not sure about the second signature at the upper left on the 10 Mil Reis. Could have been addad later by someone not connected with the issue.
As you point out it would have been crippling work for anyone to 'handwrite' every note. I wonder if they were mimeographed after the note was printed. So here goes my theory. Manufactured by the American Bank Note Company. Transported to Brazil uncut. Signature mimeographed. Sheets then cut for issue.