Really depends on what kind of coins you are talking about. If they are mint proof sets, or rolls of coins that have never been circulated, I'd say leave them in their original wrapping.
Same with coins that have been put into a protected labeled sleeve. If you can see the coin clearly, and the package they are in isn't harmful to the coin over long periods of time (some research here is needed on your part), then I don't see a benefit to removing them. They are just a high risk of being damaged.
Now, if you picked up a roll of Wheat pennies or something similar, and they are mixed up, personally I'd open them up and sort through them and see if you have anything of higher value (or make sure you weren't ripped off!). Again, handling tips and tricks should be used. Once you have looked through them, put them back in something like a coin roll or tube. Having them sitting in Crown Royal bag in your sock drawer is only going to damage them.
Maybe let us know what kind of coins you have, including the coin type, year, mint mark, and exactly what "original packaging" they came in.
And welcome!
Oldest US Coins Found
1881 Indian Head | 1934 Buffalo Nickel
1953 Roosevelt Dime | 1964 Washington Quarter
1948 Franklin Half Dollar | 1971 Eisenhower Dollar