Wow...the Cristy Drygas opener alone is worth $5! And that giant
Buffalo nickel! This has all the signs of being an authentic collection of drawer junk someone buried under their socks. It would look good in displayed a jar in the garage next to the nails and the screws.
I can't tell about the 1921 but if real it's details grade. To the right person $100 would be a fair price to pay.
"Two minutes ago I would have sold my chances for a tired dime." Fred Astaire