Grandpa's Coin Collection, Inherited.

Yes! use extreme caution.This happened to me when I was new at collecting.40 years ago I had my most valuable coins stolen RIGHT OT OF MY HOUSE.(There was no break in)I told too many people what I had!
( I had an idea who stole them)(A very close friend)

Or you could sent them to me for safe keeping....... :) Just Kiddin. Nice of Grandpa to leave you something so well put together and from his effort. RIP Grandpa. Hang on to your collection, Grandpa is look down upon us now.

If you have an interest in coins than you have a nice collection that will give you an education as you learn to grade and catalog the various types that they may reveal to you.
If you don't have an interest than, sell the entire collection. Determine how many ounces of silver you have and what silver spot is and take it to the dealer. At the least, that is what he will give you and for you it is a free gift of money. But take that money and invest in something like gold bullion and you will be ahead of the game in the long run. It will be easier to store and gold is going nowhere but up in value.
Your grandfather had his fun in building the collection. He would want you to do with it as you want.

...and this is how the sickness is passed from one generation to the next. This is exactly how I got into collecting coins. Have fun going through your collection - its a nice way to still feel connected to the ones no longer with us.