Is It Ever Worth Grading A Details Mint State Variety?

IMO Brand - a damaged coin is always damaged and will never heal.

I would not submit it knowing there is a details grade upcoming.

If it's a rarer coin and still would bring more money in value than the grading would cost. Or if you just want an attribution and don't care about the grading fees. There are plenty of Details graded coins on ebay and in auctions.

I think these are good points. From a monetary standpoint, if the details slab contributed more to resale value than the slab cost, then it might make sense. I suppose if the variety were difficult to establish on a raw coin, perhaps it would also be a good option.

Is there a difference between a Details plus variety slab and a Genuine slab with a variety attribution and an obviously details coin? I have seen both on ebay and wondered at the difference.

I had not considered the establishment of the details coin as a genuine example—I suppose that's important for coins where fakes are a concern. Would ANACS be a sensible path there? If the only relevant concern is authentication of a real coin, I don't imagine that a more expensive PCGS or NGC Details slab adds any extra value over an ANACS or CACG Details slab.