In a 2x2, your coins themselves should be well protected from any box or album you store the 2x2s in.
But what you might find is the 2x2's themselves can degrade if kept in the wrong type of plastic page. I've noticed "solvent migration" can occur from the album page into the 2x2 film, causing the film to go sticky on the outside, and hard to remove from the page.
The problem is made worse in hot weather or if the album is squeezed or compressed by, for instance, stacking several albums on top of each other and leaving them that way for years. The album on the bottom will almost certainly suffer from this effect.
The result isn't pleasant. I've been to coin shops and coin shows where the dealer has had to loan you a screwdriver, credit card or some similar wedge-shaped object so you can prise the 2x2s out of their albums. Not pretty.
There are two things you can do to avoid this.
First, don't keep albums stacked on top of each other. I keep my pages in binders that sit on a shelf, allowing the pages to hang vertically.
Second, use higher quality plastic pages. Personally, I steer completely clear of the ones made and sold specifically for coins. I've never owned one that wasn't prone to solvent migration.
Apparently, the photographic industry has done research into solvent migration (an effect which can ruin a photographic slide), and produced slide album pages that are far less prone to it. With the advent of digital cameras and the resultant demise of the photographic slide, these pages are getting harder to find, but a larger photographic supply store should still stock them. Last I checked, packs of 100 20-slot pages designed for 2x2 slides are still available at my local photo shop for for less than $40.
I've never had a problem with
PrintFile brand pages.
Don't say "infinitely" when you mean "very"; otherwise, you'll have no word left when you want to talk about something really infinite. - C. S. Lewis