With inflation over the long term you should do better with a large silver coin as mentioned above, than the nice condition $50 note.
I will open this question to everybody, as Ausjack has done.
The reason I can't answer the question for him is that I have been collecting all coins, ancient to modern for decades, and I would buy anything that jumps out at me as representing good value for money. What I could buy may be very obscure. Not a useful answer for this thread.
How would YOU spend $50 for best investment on a numismatic item, that is currently reasonably easy to obtain?