How To Determine Which Notes To Hold Onto?

You could check the Friedberg numbers for value.

I have quite few myself...200 something notes that I need to sort through.

John1 links are very good and useful for sure. Another reference would be one of the latest books:

Collector's Guide to Modern Federal Reserve Notes 1963 to 2009 by Robert Azpiazu
or
Standard Guide to Small-Size U.S. Paper Money 1928 to Date 10th Ed. by John Schwartz+Scott Lindquist

Education is key to happy collecting. Also ask reliable dealers or other collectors.

That said, as to which notes to keep. A lot depends on what makes you happy. I have notes that make me happy, but most would say "spent it". It is your collection in the end.

John and Jim both provided excellent resources to learn more about small size currency and star notes. Now I would personally recommend the books as they really are a wealth of information and readily on hand whenever you are about to make a decision whether to keep a note or not.
Pennrj430, I think if it is a relatively new note (10 yrs-20 yrs old)
It might have a small premium if in very excellent condition like Choice Un-Circulated star note
It will have a premium if it is a fancy serial star note
It will have a small premium if it is in Good to Extra Fine condition with a fancy serial number star note
It will have no premium if in less than Choice Un-Circulated condition and not a fancy serial number star note
Assuming the run has less than 640,000 notes of course as mentioned by John.

That is just my opinion and guidelines I follow.
Generally I only keep notes from 1969 and prior and I am a major star note collector.

Also if you happen to find series 1950 Federal Reserve Notes (especially those that are star notes) keep them!! They are doing quite well in the market right now.
Hope that helps!

@John1;

Where would you draw the line the line on a $100 Star.

Thanks, John

Based on what I have seen over the last few years, it's best to stay with chcu / cu notes on recent / modern short run's.

Just like every thing else prices fluctuate month to month on modern notes on ebay at times. Had many an experience of buying something for $50 per note watch it go up and down.

Also it's best to learn how to grade a raw note / un graded note by looking at a pic / scan. Some sellers are good with their descriptions Like ChCu Gem, ChCu, Cu / Au...most collectors if they trust the seller will know exactly what each term means and what the seller speaks of.

I have seen folks claim a note is chcu gem and just from looking at a scan I know it's an AU at best. The reason I bring this up is that a chcu gem can sell for $60 where as an AU is probably worth $30...big diff in price and sometimes folks get all excited they got good price on a note but they got what they paid for.

Once you get into short run $10's and higher it becomes a very limited collector base and most advanced collectors will not touch anything unless it's ChCu on a modern note. Older notes will and do get some ok premiums.

The same way woodford is looking at pre 1969 stars I look at modern / recent series short run $1, $2 and $5 stars in ChCu / ChCu gem. Soooo.. what works one person will not work for others. There are also other collectors who will just collect one denomination. FWIW, I am in the process of thinning out my collection of short run $1's as my focus has shifted more towards the $2's.

Take your time and research, research, research what you like to collect....watch ebay closing prices etc.

Ok, thanks again John. I'm learning a lot.