I dont know what you purchase or search, but I am willing to give some advice, which should cover most arenas.
If you roll or bag search, I recently posted a topic about a 1964-P die pair showing
Machine Doubling, and how to identify markers on the die set so separating them by unique die markers will take less time. If your able to look at a few coins looking for a die chip or die scratches that exist in a certain area, you can put these in piles, or small ziplock syle containers and have only a few piles to go through.
If you open penny boxes obtained through your bank, I would recommend opening a roll at a time and having a few containers / bowls / ziplock containers and some pieces of paper located near the base of each with the years written on them. It really depends what is pulled from the boxes, and how many containers you want to have on your table or desk. You could separate them into decades at first (1950/60/70/80/90/2000+) or do by mint location (Philly, Denver, San Fran).
Ive opened and sorted a box within a Saturday. I first broke the rolls down by decades (1950/1960/1970/1980) and once that was done, I had 10 containers numbered 0-9 for each invididual year.I'd start by breaking down one decade at a time, say the 1960-1969 year.
I only collect copper coins, but I DO have a cheat sheet with the years of the varieties that are from 1982-current that contain a variety that may be worth looking over. So searches by single year goes by faster, if your looking for varieties.
You could create a cheat sheet with the years and mint marks that you would like to search for. A long loose leaf paper with the years and mint marks of the varieties you would like to look for. Then if that year/muint mark is on the list, you can toss that coin into a container for further review once that roll or box has been separated.
Whatever your sorting method, it should go pretty quickly.