I'm assuming that we're talking about half dollars.
Not accounting for varieties and errors, things you should keep are:
1964 (first year of issue, 90% silver)
1965-1969 (40% silver)
1970 (40% silver, only in mint sets, struck only in Denver)
1987, 2002-present (only sold to collectors. Half dollars have not been struck for general circulation since '01)
Anything with an "S" mintmark dated 1968-present (will either be a proof or silver proof)
If you're finding really nice coins from various years, which is common (because they don't really circulate), consider starting a set of the nicest ones.
As you find better ones, keep replacing them.
The list I've written is by no means the only ones you should look for, wait for someone else to respond and discuss errors and varieties before tossing any back.
Happy Hunting!
EDIT:

to the forum!