Here Is An Idea For A Collection I Wonder If Anyone Has Tried:

a book on this topic -- Monumental Coins : Building and Structures on Ancient Coinage by Marvin Tameanko

"Monumental Coins" is a bountiful tapestry of numismatics, history and architecture that explores the buildings found on ancient coins and the historical and cultural importance of these structures. In addition to a comprehensive gallery of actual coin photos, coins are illustrated by line drawings to reveal fine structural details. Computer-generated plans of the buildings, along with freehand illustrations of building reconstructions allow complete understanding of these ancient wonders."

That would be a fun collecting theme, but like nearly every broad theme in ancient numismatics, probably impossible to complete! Like Victor said, a lot of Imperial coins feature "from life" buildings or statues, many of which (especially the Colosseum issues of Titus, which I would consider to be the crown jewel of such a collection!) are in extremely high demand and thus pricey to match.

And that's not even going into the probably thousands of provincial coins which feature temples, statues, etc.

As a side thought - we know that the numerous "Farnese Hercules" coins depict an actual statue, because archaeologists found it. Considering the static poses of various gods and goddesses over the centuries (Zeus in exactly the same pose from before Alexander's day until Maximinus II's Antioch civic coinage), we really cannot know how many coins depict actual objects versus a standardized allegorical image.