This coin just ekes in under the date limit for this subforum, but the topic relates (sort of) to another one here
http://goccf.com/t/385101 , so ...
I have had this type on my want list for a while. The reverse depicts two of the apostles (Jesus' innermost circle of followers), Saints John and James, who were brothers. St John (S IOANN), on the left, holds a cup in his left hand, and appears to have his right hand raised in blessing. The cup refers to a legend in which he is challenged by a pagan priest to drink from a cup of poison (he survived, of course). St James (S IACOB), on the right, is the one whose remains are believed by the faithful to reside in Santiago de Compostela, Spain. He is shown holding a pilgrim's walking stick in his left hand, and a book in his right; pilgrimages to Compostela were already a centuries old Christian tradition when this coin was struck.
DUchy of Urbino, mezzo paolo of Guidubaldo della Rovere, Pesaro mint, 1538-74.
Obv: Crowned arms of della Rovere family. GVI VBAL VRB DVX IIII (Guidubaldo, 4th Duke of Urbino)
Rev: Figures of Saints John and James. S IOANN S IACOB, PISAV in exergue. (Saint John, Saint James, Pesaro)

As best I can tell, this completes my collection of at least one coin with an image of each apostle.
For anyone interested in how to compile something like this, here is the list of apostles (in their order as recounted in Luke 6), and where the coins with their images were issued:
Peter - appears on innumerable coins of Italy-Papal Sates, Germany (cities like Mainz, Trier, Bremen and others that were archbishoprics) and a few other places, from medieval to modern times.
Andrew - Most common on late 17th-18th century coins of Brunswick-Lunenberg-Calenberg (Germany), but also 15th century florins of Brabant and nearby principalities
James and John - to the best of my knowledge only on a few coins of Urbino. late 15th to early 16th c.
Philip - Brabant florins circa 1500, and Portuguese India
Bartholomew - not on any coins
Matthew - a Papal States piastra of the late 1600s, and some medieval minors of Bari
Thomas - some coins of the Duchy of Parma (Italy)
James son of Alphaeus - not on any coins
Simon and Jude - medieval groschen of Goslar Germany c.1500
Judas Iscariot - not on any coins
Matthias (the apostle who replaced Judas) - medieval coins of Goslar, Germany c. 1500