The Bumble Bee release caused the Ladybug to skyrocket. Without an annual reminder and new blood entering the collecting of the series, the push for higher prices will end.
A long-lived series attracts key-date collectors and series collectors. A short one will probably fade into memory.
The 2nd and subsequent issues will probably be hardest hit. The first will always command a significant premium, but the others could drift back down to issue over time.