Most times it is just the lowest mintage for a series.
You also have to factor in availability, grade and other factors.
For example, In Lincoln cents the 1909 S vdb is considered the key.
But, IMO, a 1922 No D or 1955 double die would be harder to find and may cost
more in the higher grades.
Another example is Washington quarters, the 1932 D is considered the key.
The 1932 S has lower mintage, but being a S mint more seem to be have saved
by collectors back when they were first made. So depending on the grade
one can be higher then the other.
Best thing to do is look at a Red Book, it will show the mintage and prices.
By seeing which has the most value you can tell the keys for that series
You also have to factor in availability, grade and other factors.
For example, In Lincoln cents the 1909 S vdb is considered the key.
But, IMO, a 1922 No D or 1955 double die would be harder to find and may cost
more in the higher grades.
Another example is Washington quarters, the 1932 D is considered the key.
The 1932 S has lower mintage, but being a S mint more seem to be have saved
by collectors back when they were first made. So depending on the grade
one can be higher then the other.
Best thing to do is look at a Red Book, it will show the mintage and prices.
By seeing which has the most value you can tell the keys for that series





















